{"id":15,"date":"2020-06-12T13:22:23","date_gmt":"2020-06-12T17:22:23","guid":{"rendered":"http:\/\/192.168.1.13\/wordpress\/?page_id=15"},"modified":"2023-10-02T17:43:32","modified_gmt":"2023-10-02T21:43:32","slug":"pipeline","status":"publish","type":"page","link":"https:\/\/talonpharma.com\/index.php\/pipeline\/","title":{"rendered":"Pipeline"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"15\" class=\"elementor elementor-15\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bfe8d2f elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bfe8d2f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f275045\" data-id=\"f275045\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8e49a35 elementor-widget elementor-widget-spacer\" data-id=\"8e49a35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5fa2181 elementor-widget elementor-widget-heading\" data-id=\"5fa2181\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Pipeline<br><\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-56d90bd elementor-widget elementor-widget-text-editor\" data-id=\"56d90bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3 class=\"section-subheading text-muted\">Talon is developing oral small molecule drugs to treat Parkinson&#8217;s gait dysfunction and L-DOPA-induced dyskinesia.\u00a0<\/h3>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-be52af5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"be52af5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;slideshow&quot;,&quot;background_slideshow_gallery&quot;:[],&quot;background_slideshow_loop&quot;:&quot;yes&quot;,&quot;background_slideshow_slide_duration&quot;:5000,&quot;background_slideshow_slide_transition&quot;:&quot;fade&quot;,&quot;background_slideshow_transition_duration&quot;:500}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-0a402d1\" data-id=\"0a402d1\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-764cb66 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"764cb66\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Parkinson's Gait - TPS-100<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-10a5977 elementor-widget elementor-widget-text-editor\" data-id=\"10a5977\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><b>What is it? <\/b>Multi-targeted, fixed-dosed drug combination <sup>1 <\/sup> enhances brain cholinergic activity (acetylcholine) to improve gait in PD<\/li><li><b>Safety <\/b>&#8211; The components of TPS-100 are safe in humans<\/li><li><b>Efficacy <\/b>&#8211; TPS-100 improves balance and gait in models of Parkinsonism<\/li><li><b>What\u2019s Next? <\/b>Dose optimization studies to support Phase I clinical trials.<\/li><\/ul><p>Gait impairment and postural instability are common motor symptoms leading\u00a0 to falls and significant morbidity in Parkinson&#8217;s disease not adequately treated by L-DOPA (dopamine) therapy, suggesting other neurotransmitter systems are involved in gait.\u00a0 Recent studies suggest that the loss of both dopamine in the striatum and\u00a0 acetylcholine in the pedunculopontine and basal forebrain contribute to freezing of gait and falls.<sup>2<br \/><\/sup><\/p><p>Fixed-ratio drug combinations such as TPS-100 that target both dopamine and acetylcholine (multiple disease mechanisms)\u00a0 are expected to result in improved efficacy and reduced cost without increasing the risk of adverse effects.<sup>1<br \/><\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a8d5e4 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"1a8d5e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;zoomIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"959\" height=\"588\" src=\"\/wp-content\/uploads\/2022\/05\/ACh-DA-brain.png\" class=\"attachment-large size-large wp-image-996\" alt=\"\" srcset=\"\/wp-content\/uploads\/2022\/05\/ACh-DA-brain.png 959w, \/wp-content\/uploads\/2022\/05\/ACh-DA-brain-300x184.png 300w, \/wp-content\/uploads\/2022\/05\/ACh-DA-brain-768x471.png 768w\" sizes=\"(max-width: 959px) 100vw, 959px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-fe42c4f\" data-id=\"fe42c4f\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3449500 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3449500\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">L-DOPA-Induced Dyskinesia (LID) - Glycine Enhancers<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3bed4f8 elementor-widget elementor-widget-text-editor\" data-id=\"3bed4f8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li><b>What is it?<\/b> Glycine reuptake inhibitor (GLYT1) combined with L-DOPA therapy to improve Parkinson\u2019s treatment. <sup>3,4 <\/sup><\/li><li><b>Safety <\/b>\u2013 Extensive clinical safety data for GLYT1 inhibition<\/li><li><b>Efficacy <\/b>\u2013 Candidate reduces L-DOPA-mediated side effects such as dyskinesia and psychosis in Parkinson\u2019s<\/li><li><b>What\u2019s Next? <\/b>Studies to optimize the dose are underway in non-human primates to allow clinical trials.<\/li><\/ul><p>Levodopa (L-DOPA) is main drug used to treat Parkinson&#8217;s tremor and rigidity by increasing dopamine in the brain.\u00a0 Long term use of L-DOPA is associated with psychosis and dyskinesia, a side effect characterized by rapid involuntary movement, or slow and extended muscle spasms.\u00a0 L-DOPA-induced dyskinesia LID) and psychosis are linked to changes in neurotransmitters such as glutamate and drugs like Amantadine that directly block glutamate neurotransmission can reduce symptoms of dyskinesia but can worsen psychosis in PD.\u00a0 In contrast, enhancing glutamate activity\u00a0 by increasing the level of glycine in the brain reduce dyskinesia and psychosis.\u00a0\u00a0<sup> 3,4<br \/><\/sup><\/p><p>This work is supported by the Michael J Fox Foundation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0f198e1 elementor-widget elementor-widget-image\" data-id=\"0f198e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"285\" height=\"48\" src=\"\/wp-content\/uploads\/2023\/10\/MJFF.png\" class=\"attachment-large size-large wp-image-1017\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-0bcd495 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0bcd495\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c869b6f\" data-id=\"c869b6f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd4cb33 elementor-widget elementor-widget-text-editor\" data-id=\"fd4cb33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ol><li>Makhoba XH, Viegas C Jr, Mosa RA, Viegas FPD, Pooe OJ.<strong> Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases. <em>Drug Des Devel Ther.<\/em> 2020 Aug 11;14:3235-3249. <br \/><\/strong><\/li><li><strong>Bohnen et al. <\/strong>Cholinergic System Changes of Falls and Freezing of Gait in Parkinson\u2019s Disease. Ann Neurol.\u00a0 2019;85:538\u2013549<\/li><li>Frouni I, Belliveau S, Maddaford S, Nuara SG, Gourdon JC, Huot P. <strong>Effect of the glycine transporter 1 inhibitor ALX-5407 on dyskinesia, psychosis-like behaviours and parkinsonism in the MPTP-lesioned marmoset. <em>Eur J Pharmacol.<\/em> 2021 Nov 5;910:174452<\/strong><\/li><li>Collaboration with The Neuro (McGill University)<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Pipeline Talon is developing oral small molecule drugs to treat Parkinson&#8217;s gait dysfunction and L-DOPA-induced dyskinesia.\u00a0 Parkinson&#8217;s Gait &#8211; TPS-100 What is it? Multi-targeted, fixed-dosed drug combination 1 enhances brain cholinergic activity (acetylcholine) to improve gait in PD Safety &#8211; The components of TPS-100 are safe in humans Efficacy &#8211; TPS-100 improves balance and gait [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":740,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"full-screen","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"on","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-15","page","type-page","status-publish","has-post-thumbnail","hentry","entry","has-media"],"_links":{"self":[{"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/pages\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":205,"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":1020,"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/pages\/15\/revisions\/1020"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/media\/740"}],"wp:attachment":[{"href":"https:\/\/talonpharma.com\/index.php\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}